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Clinical Application of CAR T Cells 2019

Clinical Application of CAR T Cells 2019 Banner

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Add Event to your Calendar: Clinical Application of CAR T Cells 20193/14/2019 8:00:00 AM3/15/2019 6:00:00 PM15Zuckerman Research Center, 417 East 68th StreetFalseMM/DD/YYYY

Date & Location
Thursday, March 14, 2019, 8:00 AM - Friday, March 15, 2019, 6:00 PM, Zuckerman Research Center, 417 East 68th Street, New York, NY

Specialties
Allergy & Immunology, Gynecologic Oncology, Head and Neck Oncology, Hematology, Hematology & Oncology, Industry, Leukemia, Lymphoma, Medical Oncology, Pediatric Oncology, Pulmonary Medicine, Thoracic Medical Oncology

Overview

Chimeric antigen receptor (CAR) T-cell ("Living Drug") immunotherapy is showing promising results in the treatment of cancers. There are nine ongoing clinical trials (Phase I & II) at Memorial Sloan Kettering (MSK) and more are on track to be initiated next year. Over the years, MSK has accumulated a breadth of knowledge about developing and translating these clinical trials from bench to bedside and back to bench – constructing, manufacturing and obtaining FDA approvals for clinical grade CARs and vectors, developing universal algorithms across multiple CAR T-cell clinical trials for the treatment and management of complications, and conducting world-class correlative science.

MSK faculty, along with national and international experts, will discuss the clinical and translational aspects of cell therapies (CARs, TCRs, NKs), both for hematologic malignancies and solid tumors.

The target audience includes medical oncologists and oncology fellows, basic scientists, research fellows, nurses, clinical trial research staff, immunologists, and surgeons with an interest in tumor immunology and immunotherapy.

Keynote Speakers

Carl H. June, MD
University of Pennsylvania

Michel Sadelain, MD, PhD
Memorial Sloan Kettering Cancer Center

MSK Course Director

Prasad S. Adusumilli, MD, FACS, FCCP
Deputy Chief, Thoracic Surgery Service, Department of Surgery
Director, Mesothelioma Program
Head, Solid Tumors Cell therapy, Center for Cellular Therapeutics
Member, Center for Cell Engineering 

MSK Course Co-Directors

Renier J. Brentjens, MD, PhD
Director, Cellular Therapeutics Center
Member
Leukemia Service
Division of Hematologic Oncology
Department of Medicine

Michel Sadelain, MD, PhD
Director, Center for Cell Engineering
Member, Immunology Program
Member, Departments of Medicine and Pediatrics

Main Sessions Topics

  • Mechanisms of Relapse and Toxicity in CD19 CAR T-cell Therapies
  • TCRs and TILs
  • CARS for Myeloma
  • The Ins and Outs of Manufacturing Engineering Cells
  • Building a Clinical CAR T-cell Program
  • Novel Cell Therapies
  • Solid Tumor Cell Therapies

Breakout Session Topics

  • Meet the experts session - Attendees will have an opportunity to interact, discuss and learn from Cell Therapy Faculty in an informal dialogue. Please choose the round table session you like to participate in at registration. Options include Neurotoxicity, ICU management, CRS, QA&QC, Solid tumor cell therapy, TCRs, Multi-center trials, or Anti-PD1 strategies post cell therapy.
  • Case studies & Rapid-fire presentations
  • ABC of Cell Therapy for paramedical staff - Attendees will learn the basics of cellular therapy including the pre-clinical development, clinical translation, and regulatory requirements from medical, para-medical, nursing, and research experts involved in cellular therapy clinical trials. In addition, the essentials of designing and conducting a cell therapy clinical trial will be presented. Attendees will have opportunity to visit cell therapy lab(s), manufacturing facility, and apheresis unit involved in the investigational and commercial application of cellular therapies. At the end of the session, registered attendees will have opportunity to interact one-on-one with cell therapy experts.
  • Novel gene engineering in cell therapies
  • Operational infrastructure of commercial cell therapies

Please note the program agenda for the Non-CME Industry Sessions 6a-b and Rapid-fire Presentations will be available online soon.

Call for Abstracts

Participants are invited to submit an abstract for presentation at the course. Abstracts for the poster session will be selected on the basis of scientific merit and content quality. Presenting author(s) of selected abstracts will be notified of presentation either at the poster session or as mini-oral presentation at the Rapid-Fire session in the main program. To submit an abstract for presentation, please select 'Abstracts' above. Submission deadline: March 1, 2019.


Objectives
  1. Participants will be able to have an understanding of current CD19 CAR T-cell therapy outcomes and limitations.
  2. Participants will be able to familiarize the onset, optimal management and the results on anti-tumor efficacy of CAR T-cell toxicities
  3. To learn clinical management of patients participating in phase I clinical trials

Registration

 Registration Fees  Early*   General 
 Academia Fees      
  
 Physicians (MDs, PhDs and DOs)
 $500   $600
 Residents, Fellows, Nurses and Other Healthcare Providers     
 $200 
 $300 
 Industry Fees


 All Members (any employee working for a commercial interest**)       n/a  $1,500 

*Early Registration - Apply promo code CARTC19E at checkout (deadline extended to February 1, 2019)
**Industry professionals may attend MSK CME activities for their own education. Marketing, sales, and promotion of products and services is strictly prohibited at MSK CME activities. The ACCME defines a commercial interest as “any entity producing, marketing, re-selling, or distributing health care goods or services consumed by, or used on, patients. The ACCME does not consider providers of clinical service directly to patients to be commercial interests. Please click here for more information or email cme@mskcc.org if you have additional questions.

Course registration includes continental breakfast, lunch, and refreshment breaks. Please contact cme@mskcc.org at least one week prior to the course if you have any special dietary requests or require any specific accommodations.

Registration Discounts/Promotions

  • MSK CME offers a 30% discounted rate for MSK Alumni, MSK Cancer Alliance and Cancer Care Partners. If you are a member of one of these groups, please contact cme@mskcc.org for more information.
  • MSK Employee Registration Waitlist. MSK staff interested in registering for this course should join the waitlist. We will notify you before the course if space is available.

Please note: after your payment has been processed, no further promotional discount adjustments will be made to your registration.

Cancellation Policy

If you cancel your participation in this course, your registration fee, less a $75 administrative fee, will be refunded when email notification is received by the MSK Office of Continuing Medical Education (MSK CME) at least 7 days prior to the first day of the course (cme@mskcc.org).

Cancellations or no-shows after this date are not eligible for a refund. MSK CME reserves the right to cancel or postpone any course due to unforeseen circumstances. In the unlikely event we must cancel or postpone this course, we will refund the registration fee in full, but are not responsible for any related costs, charges, or expenses to participants, including fees incurred by airline/travel/lodging agencies. At any time, you may substitute another registrant in your place after contacting MSK CME with the relevant information.


Accreditation

Memorial Sloan Kettering Cancer Center is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

AMA Credit Designation Statement

MSK designates this live activity for a maximum of 15.25 AMA PRA Category 1 Credits™. Physicians should claim only credit commensurate with the extent of their participation in the activity.

CME hours from this conference qualify for the Federation for the Accreditation of Cellular Therapy (FACT) Immune Effector Cells (IEC) annual training requirement (10 hrs needed).

 

 

Keynote Speakers

Carl H. June, MD
University of Pennsylvania

Michel Sadelain, MD, PhD
Memorial Sloan Kettering Cancer Center

 

MSK Course Director 

Prasad S. Adusumilli, MD, FACS, FCCP   
Deputy Chief, Thoracic Surgery Service, Department of Surgery
Director, Mesothelioma Program
Head, Solid Tumors Cell therapy, Center for Cellular Therapeutics
Member, Center for Cell Engineering 

MSK Course Co-Directors

Renier J. Brentjens, MD, PhD
Director, Cellular Therapeutics Center
Member
Leukemia Service
Division of Hematologic Oncology
Department of Medicine

Michel Sadelain, MD, PhD
Director, Center for Cell Engineering
Member, Immunology Program
Member, Departments of Medicine and Pediatrics 

Invited Course Faculty (CME Session)

Chantale Bernatchez, PhD
Assistant Professor, Melanoma Medical Oncology
The University of Texas MD Anderson Cancer Center
Houston, TX

Michael R. Bishop, MD
Professor, Medicine
Director, Hematopoietic Stem Cell Transplantation
University of Chicago
Chicago, IL

Challice Bonifant, MD, PhD
Assistant Professor, Pediatric Oncology
Sidney Kimmel Comprehensive Cancer Center
Johns Hopkins University School of Medicine
Baltimore, MD

Adam D. Cohen, MD
Director, Myeloma Immunotherapy 
Assistant Professor, Medicine
University of Pennsylvania
Philadelphia, PA

Kenneth G. Cornetta, MD
Professor, Clinical Medical & Molecular Genetics 
Indiana University School of Medicine
Indianapolis, IN

Marco L. Davila, MD, PhD
Associate Member
Moffitt Cancer Center, University of South Florida
Tampa, FL

John DiPersio, MD, PhD
Deputy Director, Alvin J. Siteman Cancer Center 
Chief, Division of Oncology
Siteman Cancer Center
Washington University School of Medicine 
Saint Louis, MO

Gianpietro Dotti, MD
Professor, Department of Microbiology and Immunology
University of North Carolina Cancer Center
Chapel Hill, NC 

Stephen J. Forman, MD
Professor and Chair, Department of Hematology & Hematopoietic Cell Transplantation
Director, T Cell Immunotherapy Laboratory 
City of Hope Comprehensive Cancer Center
Duarte, CA

Joseph A. Fraietta, PhD
Director, Solid Tumor Immunotherapy Laboratory Center for Advanced Cellular Therapeutics 
University of Pennsylvania
Philadelphia, PA

Adrian P. Gee, PhD
Director, Cell Processing and Vector Production Core Laboratory
Professor, Department of Pediatrics
Baylor College of Medicine
Houston, TX

Stephen Gottschalk, MD
Chair, Department of Bone Marrow Transplantation & Cellular Therapy
St. Jude Children’s Research Hospital
Memphis, TN

Damian Green, MD
Associate member
Fred Hutchinson Cancer Center
Seattle, WA

Michael D. Jain, MD, PhD
Assistant Professor, Oncologic Sciences 
Moffitt Cancer Center, University of South Florida
Tampa, FL

Carl H. June, MD
Director, Center for Cellular Immunotherapies
Professor, Department of Pathology and Laboratory Medicine 
University of Pennsylvania
Philadelphia, PA

Marcela V. Maus, MD, PhD
Assistant Professor, Medicine, Harvard Medical School
Director of Cellular Immunotherapy, Cancer Center
Massachusetts General Hospital
Boston, MA

Daniel J. Powell Jr., PhD
Associate Professor, Pathology and Laboratory Medicine
University of Pennsylvania
Philadelphia, PA

Katy Rezvani, MD, PhD
Professor, Department of Stem Cell Transplantation 
Division of Cancer Medicine
The University of Texas MD Anderson Cancer Center
Houston, TX

Nirali Shah, MD, MHSc
Associate Research Physician, Pediatric Oncology Branch
National Cancer Institute
Bethesda, MD

Elizabeth J. Shpall, MD
Professor and Director, Cell Therapy Laboratory
Deputy Department Chair, Stem Cell Transplantation
The University of Texas MD Anderson Cancer Center
Houston, TX

Verena Staedtke, MD, PhD
Director, Pediatric Neurofibromatosis
Assistant Professor, Neurology
Johns Hopkins Hospital 
Baltimore, MD

David Stroncek, MD
Senior Clinician, Transfusion Medicine Department
National Cancer Institute
Bethesda, MD

Anthony R. Welch, PhD
Program Director 
Biological Resources Branch 
National Cancer Institute
Bethesda, MD


 

Invited Course Faculty (Industry Session)

Mauro Avanzi, MD, PhD
Director, Medical Research
Kite Pharma
Los Angeles, CA

Sharon Benzeno
SVP Research and Business Development
Adaptive Biotechnologies
Seattle, WA

Stephanie Farnia, MPH
Director, Clinical Value
Blue Cross Blue Shield Association
Madison, WI

William Go, MD, PhD
Senior Vice President, Development
A2 Biotherapeutics 
Agoura Hills, CA

Christopher Haqq, MD, PhD
Chief Scientific Office
ATARA Biotherapeutics
San Francisco, CA

Bruce McCreedy, PhD
Senior Vice President, Immuno-Oncology
Precision Biosciences
Durham, NC


Fyodor Urnov, PhD
Deputy Director
Altius Institute for Biomedical Sciences
Seattle, WA

Loïc Vincent, PhD
Head of Cell Therapy Discovery
Takeda Pharmaceuticals International Co. 
Cambridge, MA 

Travis Young, PhD
VP Biologics
Calibr - The California Institute for Biomedical Research
La Jolla, CA

 

MSK Course Faculty 

Kevin J. Curran, MD
Assistant Attending 
Bone Marrow Transplant Service

Sandra P. D’Angelo, MD
Assistant Attending, Medical Oncology

Yashodhara Dash, MD, PhD, MBA
Senior Director, Tech Mgmt & Comm Research and Technology Mgmt

Lisa DeAngelis, MD
Physician-in-Chief

Claudia Diamonte, RN

Mark B. Geyer, MD
Assistant Attending
Leukemia Service

Sergio A. Giralt, MD
Chief attending
Adult Bone Marrow Transplant Service

Elizabeth F. Halton, NP

Aisha N. Hasan, MD
Assistant Professor, Pediatrics 
Weill Cornell Medicine 

Scott James, MD, PhD
Assistant Attending, Medicine

Christopher A. Klebanoff, MD
Head, Breast Immunotherapy Section 

C. Ola Landgren, MD, PhD
Chief, Myeloma Service

Sham Mailankody, MD
Assistant Attending, Medical Oncology

Elena Mead, MD
Assistant Attending
Critical Care Medicine Service 

Roisin E. O’Cearbhaill, MD
Assistant Attending, Medicine

M. Lia Palomba, MD
Associate Attending
Lymphoma Service

Jae Park, MD
Assistant Attending
Leukemia Service

Miguel-Angel Perales, MD
Deputy Chief, Adult Bone Marrow Transplant Service
Director, Adult Bone Marrow Transplantation 

Isabelle Rivière, PhD
Director, Cell Therapy and Cell Engineering Facility

Bianca D. Santomasso, MD, PhD
Assistant Attending 
Neurology Service 

Craig S. Sauter, MD
Assistant Attending
Bone Marrow Transplant Service

David A. Scheinberg, MD, PhD
Chair, Molecular Pharmacology Program
Director, Experimental Therapeutics Center

Eric Smith, MD, PhD
Director, Clinical Translation 
Cellular Therapeutics Center

Craig B. Thompson, MD
President

Marcel R. van den Brink, MD, PhD
Head, Division of Hematologic Malignancies

Xiuyan Wang, PhD
Assistant Director, Cell Engineering Facility

 

Faculty Disclosures (All Faculty)

Prasad S. Adusumilli, MD
Attending
MSK
New York, NY
Chantale Bernatchez, PhD
Assistant Professor
The University of Texas MD Anderson Cancer Center
Pearland, TX
Michael R. Bishop, MD

University of Chicago
Burr Ridge, IL
Challice Bonifant, MD
Assistant Professor
Johns Hopkins University School of Medicine
Towson, MD
Renier J Brentjens, MD
Attending
MSK
New York, NY
Adam. D Cohen, MD
Assistant Professor
University of Pennsylvania
Philadelphia, PA
Kenneth G. Cornetta, MD

Indiana University School of Medicine
Kevin J Curran, MD
Assistant Attending
MSK
Fairfield, CT
Sandra P. D'Angelo, MD
Assistant Attending
MSK
New York, NY
Marco L. Davila, MD, PhD
Associate Member
Moffitt Cancer Center, University of South Florida
Tampa, FL
John F DiPersio, MD
Chief, Division of Oncology
Siteman Cancer Center, Washington University School of Medicine
St. Louis, MO
Gianpietro  Dotti, MD

University of North Carolina Cancer Center
Stephen J. Forman, MD
Chair, Dept. Hem/HCT
City of Hope Comprehensive Cancer Center
Duarte, CA
Josheph A. Fraietta, PhD

University of Pennsylvania
Adrian P. Gee, PhD

Baylor College of Medicine
Mark B Geyer, MD
Assistant Attending L1
MSK
New York, NY
Sergio Giralt, MD
Chief Attending
MSK
New York, NY
Stephen Gottschalk, MD

St. Jude Children's Research Hospital
Memphis, TN
Damian Green, MD

Fred Hutchison Cancer Center
Elizabeth F. Halton, ANP
Clin Trials Nurse Practitioner
MSK
East Northport, NY
Michael D Jain, PhD
Assistant Member
Moffitt Cancer Center, University of South Florida
Tampa, FL
Carl H. June, MD

University of Pennsylvania
Philadelphia , PA
Christopher A Klebanoff, MD
Assistant Attending
MSK
New York, NY
Carl Landgren, MD, PhD
Chief Attending
MSK
New York, NY
Sham Mailankody, MBBS
Assistant Attending L1
MSK
New York, NY
Marcela V. Maus, MD, PhD
Director of Cellular Immunotherapy
Massachusetts General Hospital
Lexington, MA
Elena Mead, MD
Assistant Attending
MSK
Maria Palomba, MD
Associate Attending
MSK
New York, NY
Jae Park, MD
Assistant Attending
MSK
New York, NY
Miguel-Angel Perales, MD
Associate Attending
MSK
New York, NY
Danniel J. Powell Jr., PhD

University of Pennsylvania
Katy Rezvani, MD, PhD

The University of Texas MD Anderson Cancer Center
houston, TX
Isabelle Riviere, PhD
Laboratory Member
MSK
New York, NY
Michel Sadelain, MD, PhD
Member
MSK
Bianca D. Santomasso, MD, PhD
Assistant Attending L1
MSK
New York, NY
Craig S Sauter, MD
Assistant Attending
MSK
New York, NY
David A Scheinberg, MD
Member
MSK
ny, NY
Nirali Shah, MD, MHSc

National Cancer Institute
Elizabeth Shpall, MD

The University of Texas MD Anderson Cancer Center
Houston , TX
Eric L Smith, MD
Assistant Attending L1
MSK
Scarsdale, NY
Verena Staedtke, MD
Assistant Professor
Johns Hopkins Hospital?
Baltimore, MD
David Stroncek, MD

National Cancer Institute
Marcel Van Den Brink, MD,PhD
Div Head Attending
MSK
New York, NY
Xiuyan Wang, PhD
Associate Lab Member
MSK
Anthony Welch, PhD

NCI/NIH
Frederick, MD

Abstract Submission

Memorial Sloan Kettering Cancer Center (MSK) is pleased to invite you to submit an abstract. Abstracts will be selected on the basis of their scientific merit and content quality.

Presenting author(s) of selected abstracts will be notified of presentation either at the poster session or as mini-oral presentation at the Rapid-Fire session in the main program.

Guidelines for poster and mini-oral presentation will be sent to selected abstract authors after acceptance.

Submission Deadline:

Materials must be received by MSK by 11:59 pm EST on March 1, 2019.



Submit your Abstract

 

 

 

Memorial Sloan Kettering gratefully acknowledges the following organizations for providing educational grants or financial support for this live activity:

  • Adaptive Biotechnologies
  • Allogene Therapeutics, Inc.
  • Atara Biotherapeutics
  • Miltenyi Biotec
  • Takeda Pharmaceuticals USA, Inc.

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