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Clinical Application of CAR T Cells 2017


Clinical Application of CAR T Cells 2017 Banner

  • Overview
  • Register
  • Brochure
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Add to Calendar Clinical Application of CAR T Cells 2017 11/16/2017 8:00:00 AM 11/17/2017 5:00:00 PM America/New_York For More Details: https://mskcc.cloud-cme.com/course/courseoverview?EID=2614 Description: Chimeric antigen receptor (CAR) T-cell (’Living Drug’) immunotherapy is showing promising results in the treatment of cancers. There are nine ongoing clinical trials (Phase I & II) at Memorial Sloan Kettering (MSK) and more are on track to be initiated next year. Over the years, MSK has accumulated a breadth of knowledge about developing and translating these clinical trials from bench to bedsid... Zuckerman Research Center 417 E 68th St false MM/DD/YYYY


Date & Location
Thursday, November 16, 2017, 8:00 AM - Friday, November 17, 2017, 5:00 PM, Zuckerman Research Center 417 E 68th St

Specialties
Specialties - Allergy and Immunology, Bone Marrow Transplant, Breast Medical Oncology, Leukemia, Lymphoma, Oncology and Hematology, Solid Tumor Oncology, Thoracic Medical Oncology

Overview

Chimeric antigen receptor (CAR) T-cell (’Living Drug’) immunotherapy is showing promising results in the treatment of cancers. There are nine ongoing clinical trials (Phase I & II) at Memorial Sloan Kettering (MSK) and more are on track to be initiated next year. Over the years, MSK has accumulated a breadth of knowledge about developing and translating these clinical trials from bench to bedside – choosing the ideal antigen target, constructing clinical grade CARs and vectors, investigating CARs in clinically relevant models, manufacturing, quality control, developing protocols for FDA approval, optimizing consent forms that cover emerging ethical issues, managing complications, and conducting world-class correlative science.

MSK faculty, along with national and international experts, will discuss the clinical and translational aspects of cell therapies (CARs, TCRs, NKs), both for hematologic malignancies and solid tumors. 

Participants are invited to join the course faculty for a networking reception at Rockefeller University’s Weiss Café on November 16th.

Rockefeller University
1230 York Avenue, New York, NY
5:00-7:00 pm

CALL FOR ABSTRACTS (deadline: November 10, 2017)

Participants are invited to submit an abstract for presentation at the course. Abstracts for the poster session will be selected on the basis of scientific merit and content quality. To submit an abstract for presentation, please select 'Abstracts' above. 

Main Sessions

  • CARs for B-cell Malignancies
  • Managing Toxicities
  • The Ins and Outs of Manufacturing Engineered Cells
  • CARs for Non-B-cell Hematologic Malignancies
  • Non-T-cell Therapies
  • Novel Cell-based Technologies
  • TCRs and BiTEs
  • National Guidelines for CAR T-cell Therapy Programs
  • CARs for Solid Tumors

Breakout Session Topics

  • Clinical and Operational Infrastructure of Engineered Cell Therapy
  • Novel T-cell-based Technologies and Assays

Optional Non-CME Industry Sessions

There will be two optional non-CME industry sessions for attendees, one on Thursday from 3:45pm - 5:00pm and another on Friday from 9:15am - 10:45am. Please note that Memorial Sloan Kettering Cancer Center will not be offering CME credits for the either industry session.
View the industry sessions agenda.

Target Audience

The target audience includes medical oncologists and oncology fellows in training, basic scientists, research fellows in training, nurses, clinical trial research staff, immunologists, and surgeons with an interest in tumor immunology and immunotherapy.

Sponsors

Memorial Sloan Kettering gratefully acknowledges the following organizations for providing educational grants or financial support for this live activity:

  • ACEA Biosciences, Inc.
  • Adaptive Biotechnologies 
  • Eureka Therapeutics, Inc.
  • Juno Therapeutics
  • Kite, a Gilead Company
  • Novartis

Objectives
  1. To learn new developments in CAR T-cell therapy
  2. To learn patient toxicity management
  3. To learn patient clinical tiral management algorithms

Registration

Registration Fees Early*       General  
 Academia Fees      
  
 Physicians (MDs, PhDs and DOs)
$500 $600  
 Residents, Fellows, Nurses and Other Healthcare Providers     
$200
$300 
 Industry Fees


 All Members (any employee working for a commercial interest**)       n/a $1,500

*Early Registration - Apply promo code CARTEARLY7 at checkout (deadline 10/30/2017)
**The ACCME defines a commercial interest as “any entity producing, marketing, re-selling, or distributing health care goods or services consumed by, or used on, patients. The ACCME does not consider providers of clinical service directly to patients to be commercial interests. Please click here for more information or email [email protected] if you have additional questions. 

Registration Details

Registration includes continental breakfast, lunch, and refreshment breaks. Please contact [email protected] at least one week prior to the course if you have any special dietary needs.

  • 30% Discounted Rate for MSK Alumni and MSK Alliance Members 
    MSK offers a discounted rate to all MSK Alumni and MSK Alliance members to attend a CME course. Please contact [email protected] for a promo code or more information. 
  • MSK Employee Registration Waitlist  
    MSK staff interested in registering for this course should join the waitlist. We will notify you before the course if space is available.

Cancellation Policy

If you cancel your participation in this course, your registration fee, less a $75 administrative fee, will be refunded when email notification is received by the MSK Office of Continuing Medical Education (MSK CME) at least 7 days prior to the first day of the course ([email protected]).

Cancellations or no-shows after this date are not eligible for a refund. MSK CME reserves the right to cancel or postpone any course due to unforeseen circumstances. In the unlikely event we must cancel or postpone this course, we will refund the registration fee in full, but are not responsible for any related costs, charges, or expenses to participants, including fees incurred by airline/travel/lodging agencies. At any time, you may substitute another registrant in your place after contacting MSK CME with the relevant information.


Accreditation

Memorial Sloan Kettering Cancer Center is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians

AMA Credit Designation

Memorial Sloan Kettering Cancer Center designates this live activity for a maximum of 10 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Please note that Memorial Sloan Kettering Cancer Center will not be offering CME credits for the optional non-CME industry sessions.

CME hours from this conference qualify for the Federation for the Accreditation of Cellular Therapy (FACT) Immune Effector Cells (IEC) annual training requirement (10 hrs needed).

CE Credits

This course will not offer nursing CE credits. Nurses will receive a non-physician CME certificate for AMA PRA Category 1 Credit(s)™.  Certain nursing certification providers (such as ANCC) may accept this certificate for CE requirements. Please check with your certification providers for more information. 



Keywords:



 

MSK Course Director

Prasad S. Adusumilli, MD, FACS, FCCP   
Member, Center for Cell Engineering & Center for Cellular Therapeutics
Deputy Chief, Thoracic Surgery Service
Department of Surgery

 

MSK Co-Course Directors

Renier J. Brentjens, MD, PhD
Director, Cellular Therapeutics Center
Associate Attending
Leukemia Service
Division of Hematologic Oncology
Department of Medicine

Michel Sadelain, MD, PhD
Director, Center for Cell Engineering
Member, Immunology Program
Member, Departments of Medicine and Pediatrics 

 

MSK Faculty 

Kevin J. Curran, MD
Assistant Attending
Bone Marrow Transplant Service
Department of Pediatrics

Jeffrey Drebin, MD
Chairman Attending
Department of Surgery

Justin Eyquem, PhD
Research Fellow
Sadelain Lab
Immunology Program

Sergio A. Giralt, MD
Chief, Adult Bone Marrow Transplant Service
Division of Hematologic Oncology
Department of Medicine

Philip Kantoff, MD
Chairman Attending
Department of Medicine

Christopher A. Klebanoff, MD
Assistant Attending
Breast Medicine Service
Division of Solid Tumor Oncology
Department of Medicine

Andrew Kung, MD, PhD
Chairman Attending 
Department of Pediatrics

Elena Mead, MD
Assistant Attending
Critical Care Medicine Service
Department of Anesthesiology and Critical Care Medicine

Roisin O’Cearbhaill, MD
Assistant Attending
Gynecologic Medicial Oncology Service
Division of Solid Tumor Oncology
Department of Medicine

Lia Palomba, MD
Associate Attending
Lymphoma Service
Division of Hematologic Oncology
Department of Medicine

Jae Park, MD
Assistant Attending
Leukemia Service
Division of Hematologic Oncology
Department of Medicine

Miguel Perales, MD
Deputy Chief, Adult Bone Marrow Transplant Service
Division of Hematologic Oncology
Department of Medicine

Isabelle Riviere, PhD
Director, Cell Therapy and Cell Engineering Facility

Paul Sabbatini, MD
Deputy Physician-in-Chief for Clinical Research

Bianca Santomasso, MD
Instructor, Neurology Service
Department of Neurology

Craig Sauter, MD
Assistant Attending
Bone Marrow Transplant Service
Division of Hematologic Oncology
Department of Medicine

David A. Scheinberg, MD, PhD
Chair, Molecular Pharmacology Program
Director, Experimental Therapeutics Center

Eric Smith, MD, PhD
Assistant Attending
Myeloma Service
Division of Hematologic Oncology
Department of Medicine

Craig B. Thompson, MD
President and Chief Executive Officer

William Travis, MD
Director, Thoracic Pathology
Department of Pathology

Stephen Solomon, MD
Chief Attending
Interventional Radiology Service
Department of Radiology

 

Invited Faculty (CME Session)

Joachim Aerts, MD, PhD
Professor, Department of Pulmonary Disease
Erasmus University Medical Center

Christopher Choi, PhD
Member, Center for Immunotherapy
Roswell Park Cancer Institute

Marco Davila, MD, PhD
Associate Member
Department of Blood and Marrow Transplantation
Moffitt Cancer Center

Gianpietro Dotti, MD
Professor, Department of Microbiology and Immunology
University of North Carolina

Rong Fan, PhD
Associate Professor
Biomedical Engineering
Yale University

Terry Fry, MD
Head, Hematologic Malignancies Section
National Cancer Institute

Saar Gill, MD, PhD
Assistant Professor
Department of Medicine
Hospital of the University of Pennsylvania

Stephen Gottschalk, MD
Chair, Department of Bone Marrow Transplantation and Cellular Therapy
St. Jude Children’s Research Hospital

Philip Greenberg, MD
Member and Head, Program in Immunology
Fred Hutchinson Cancer Research Center

Helen Heslop, MD, DSc (Hon)
Director, Center for Cell and Gene Therapy
Texas Children’s Hospital

Anahid Jewett, MPH, PhD
Professor, Section of Oral Biology
Division of Oral Biology and Medicine
University of California, Los Angeles

Frederick Locke, MD
Associate Member and Vice Chair
Department of Blood and Marrow Transplant and Cellular Immunotherapy
Moffitt Cancer Center

Marcela Maus, MD, PhD
Director of Cellular Immunotherapy
Massachusetts General Hospital

Edmund Moon, MD
Assistant Professor
Department of Medicine
Hospital of the University of Pennsylvania

Sarah Nikiforow, MD, PhD
Instructor in Medicine
Hematologic Oncology Treatment Center
Dana-Farber Cancer Institute

Katy Rezvani, MD, PhD
Professor, Department of Stem Cell Transplantation
The University of Texas
MD Anderson Cancer Center

 

Invited Faculty (Industry Session)

Yama Abassi, PhD
Vice President, Global Strategic Business Development and Growth
ACEA Biosciences

Adria Carbo, PhD
Associate Director of Business Development
Adaptive Biotechnologies

Elizabeth Faust, PhD
Vice President, Medical Affairs
Kite Pharma

Aaron Foster, MD
Vice President, Product Discovery
Bellicum Pharmaceuticals

Christopher Keir, MD, MS
Vice President
Global Head of Cell and Gene Medical Affairs
Novartis Pharmaceuticals Corporation

Hyam Levitsky, MD
Executive Vice President of Research and Chief Scientific Officer
Juno Therapeutics

Julianne Smith, PhD
Group Leader, Cellectis Therapeutics

 

Faculty Disclosures (All Faculty)



Member Information
Role in activity
Nature of Relationship(s) / Name of Ineligible Company(s)
Yama Abassi, PhD
ACEA Biosciences
Faculty
Prasad S. Adusumilli, MD
MSK
Faculty
Nothing to disclose
Joachim Aerts, MD, PhD
Erasmus University of Medical Center
Faculty
Consulting Fee-Merck and Company, Inc.|Consulting Fee-Eli Lilly and Company|Consulting Fee-Bristol-Myers Squibb|Consulting Fee-Boehringer Ingelheim Vetmedica GmbH|Receipt of Intellectual Property Rights/Patent Holder|Consulting Fee-AstraZeneca
Renier Brentjens, MD, PhD
Roswell Park Comprehensive Cancer Center
Faculty
co-founder, stockholder and consultant -JUNO Therapeutics
Adria Carbo, PhD
Adaptive Biotech
Faculty
Nothing to disclose
Christopher Choi, PhD
Roswell Park Cancer Institute
Faculty
Nothing to disclose
Kevin J Curran, MD
Memorial Sloan Kettering Cancer Center
Faculty
Nothing to disclose
Marco L. Davila, MD, PhD
Moffitt Cancer Center, University of South Florida
Faculty
Consulting Fee-Kite Pharma|Consulting Fee-Servier|Consulting Fee-Celyad|Consulting Fee-Precision Biosciences
Gianpietro  Dotti, MD
University of North Carolina Cancer Center
Faculty
Jeffrey Drebin, MD
MSK
Faculty
Salary-Spouse - Luitpold Pharma|Ownership Interest-Roche|Ownership Interest-ISIS Pharmaceuticals, Inc.|Ownership Interest
Rong Fan, PhD
Yale University
Faculty
Co-founder-IsoPlexis Corporation|Scientific Advisory Board-Bio-Techne (R&D Systems, Protein Simple, ACD etc.)
Elizabeth Faust, PhD
Kite Pharma
Faculty
Aaron Foster, MD
Bellicum Pharmaceuticals
Faculty
Terry Fry, MD
National Cancer Institute
Faculty
Nothing to disclose
Saar Gill, MD
Hospital of the University of Pennsylvania
Faculty
Ownership Interest-CARMA Therapeutics|Contracted Research-Novartis AG
Faculty Photos
Sergio Giralt, MD
MSK
Faculty
Consulting Fee-Abbvi|Consulting Fee-Celgene|Consulting Fee-Amgen|Consulting Fee-Sanofi|Consulting Fee-Takeda Pharmaceuticals, Inc.|Consulting Fee-Johnson and Johnson|Consulting Fee-Jazz|Consulting Fee-Novartis AG|Contracted Research-Sanofi-Aventis|Contracted Research-Takeda Pharmaceuticals, Inc.|Contracted Research-Miltenyi|Contracted Research-Sanofi
Stephen Gottschalk, MD
St. Jude Children's Research Hospital
Faculty
Receipt of Intellectual Property Rights/Patent Holder-CellMedica|Contracted Research-TESSA Therapeutics
Philip D Greenberg, MD
Fred Hutchinson Cancer Research Center
Faculty
Ownership Interest-Juno Therapeutics|Consulting Fee-Juno Therapeutics
Helen Heslop, MD, DSc (Hon)
Baylor College of Medicine
Faculty
Contracted Research-Cell Medica|Consulting Fee-Novartis AG|Ownership Interest-Viracyte|Ownership Interest-Marker Therapeutics
Anahid Jewett, PhD, MPH
University of California, Los Angeles
Faculty
Nothing to disclose
Christopher Keir, MD

Faculty
Christopher A Klebanoff, MD
MSK
Faculty
Ownership Interest-KITE pharma
Andrew L Kung, MD, PhD
MSK
Faculty
Consulting Fee-Darwin Health
Hyam Levitsky, MD
Juno Therapeutics
Faculty
Frederick Locke, MD
Moffitt Cancer Center
Faculty
Consulting Fee-Cellular BioMedicine Group Inc
Marcela Maus, MD, PhD
Massachusetts General Hospital Cancer Center
Faculty
Consultant -Adaptimmune|Consultant-Adaptive Biotechnologies|Consultant-Agenus Bop|Consultant-Bluebird Bio|Consultant-Cell Design Lab|Consultant-Cellectis (SAB)|Consultant-CRISPR Therapeutics|Consultant-Kite Pharma|Consultant-Neon|Consultant-Obsidian|Consultant-Unum|consultant-TCR2 (SAB)|Consultant-WindMIL (SAB)
Elena Mead, MD
MSK
Usa
Faculty
Nothing to disclose
Edmund Moon, MD
Hospital of the University of Pennsylvania
Faculty
Nothing to disclose
Robert J. Motzer, MD
MSK
Faculty
Consulting Fee-Bavarian Nordic|Consulting Fee-DRGT|Consulting Fee-Genentech, Inc.|Consulting Fee-Janssen|Consulting Fee-Merck and Company, Inc.|Consulting Fee-Metamark|Consulting Fee-OncoCellMDX|Consulting Fee-Progenity|Consulting Fee-Sanofi-Aventis|Consulting Fee-Tarveda|Consulting Fee-Context Therapeutics, LLC|Consulting Fee-GE Healthcare Bio-Sciences|Consulting Fee-New England Research Institutes, Inc.|Consulting Fee-Thermo Fisher
Sarah Nikiforow, MD
Dana-Farber Cancer Institute
Faculty
Speakers Bureau-Kite Pharma
Roisin O'Cearbhaill, MD
MSK
Faculty
Advisory Board-Tesaro
Lia Palomba, MD
MSK
Faculty
Nothing to disclose
Jae Park, MD
MSK
Faculty
Nothing to disclose
Miguel Perales, MD
MSK
Faculty
Consulting Fee-Servier|Consulting Fee-Merck and Company, Inc.|Consulting Fee-Incyte|Consulting Fee-Seattle Genetics
Katy Rezvani, MD, PhD
The University of Texas MD Anderson Cancer Center
Faculty
Nothing to disclose
Isabelle Riviere, PhD
MSK
Faculty
Consulting Fee-Juno Therapeutics|Contracted Research-Juno Therapeutics|Ownership Interest-Juno Therapeutics
Paul Sabbatini, MD
MSK
Faculty
Contracted Research-Bristol-Myers Squibb Sanofi Pharmaceuticals Partnership
Michel Sadelain, MD, PhD, Director
MSK
Faculty
Consulting Fee
Bianca D. Santomasso, MD, PhD
MSK
Faculty
Consulting Fee-Juno Therapeutics|Consulting Fee-Kite Pharma
Craig S Sauter, MD
MSK
Faculty
Consulting Fee-Sanofi-Aventis|Contracted Research-Juno Therapeutics|Contracted Research-Sanofi-Aventis
David A Scheinberg, MD
MSK
Faculty
stock, fees-Eureka, Sellas
Julianne Smith, PhD

Faculty
Stephen Solomon, MD
MSK
Faculty
Consulting Fee-Johnson and Johnson|Consulting Fee-Medtronic, Inc.|Consulting Fee-AstraZeneca|Ownership Interest-Aspire Bariatrics|Ownership Interest-Aperture Medical|Ownership Interest-Adgero|Contracted Research-GE Healthcare Bio-Sciences
Craig B Thompson, MD
Memorial Sloan Kettering Cancer Center
Faculty
William Travis, MD
MSK
Faculty
Nothing to disclose

Thursday, November 16, 2017
 
Day 1

Welcome & Introduction
8:45AM - 8:50AM
Prasad S. Adusumilli, MD
Inaugural Remarks
8:50AM - 9:00AM
Craig B Thompson, MD
Clinical Trials for B-cell ALL: the MSK Experience
9:00AM - 9:15AM
Jae Park, MD
CD22 CAR T-cell Therapy
9:15AM - 9:30AM
Terry Fry, MD
CD19 CAR T-cell Therapy for Relapsed and Refractory B-cell NHL
9:30AM - 9:45AM
Lia Palomba, MD
Clinical Trials for B-cell NHL: the Moffitt Cancer Center Experience
9:45AM - 10:00AM
Frederick Locke, MD
Neurotoxicity in CD19 CAR T-cell Clinical Trials
10:30AM - 10:45AM
Bianca D. Santomasso, MD, PhD
CAR T-cell Toxicity Management Algorithms
10:45AM - 11:00AM
Marco L. Davila, MD, PhD
ICU Management of CAR T-cell Patients: Evolving Changes
11:00AM - 11:15AM
Elena Mead, MD
Evolution of CAR Manufacturing at MSK
11:30AM - 11:45AM
Isabelle Riviere, PhD
IL18 Armored CARs
1:00PM - 1:15PM
Renier Brentjens, MD, PhD
Combination of Ibrutinib and CD19 CARs for CLL
1:15PM - 1:30PM
Marcela Maus, MD, PhD
BCMA-targeted CAR T-cell Therapy
1:30PM - 1:45PM
CAR-directed NK Cell Therapy
2:00PM - 2:15PM
Katy Rezvani, MD, PhD
Supercharged NK Cells for Cancer Therapy
2:15PM - 2:30PM
Anahid Jewett, PhD, MPH
Dendritic Cell-based Immunotherapy for Solid Tumors
2:30PM - 2:45PM
Joachim Aerts, MD, PhD
Single-cell Analysis in Cell Therapy
3:15PM - 3:30PM
Rong Fan, PhD
T-cell Gene Editing
3:30PM - 3:45PM
Friday, November 17, 2017
 
Day 2

Welcome Address
9:00AM - 9:15AM
TCR Mimic Antibodies for Bispecific T-cell Engager Antibodies and CAR T cells
10:45AM - 11:00AM
David A Scheinberg, MD
Adoptive Immunotherapy for Solid Cancers Using TCR Engineered T-cell Subsets
11:00AM - 11:15AM
Christopher A Klebanoff, MD
Keynote Address: Next Generation of TCR-based Immunotherapies
11:15AM - 11:45AM
Philip D Greenberg, MD
Rise of Immunotherapy in Oncology: How we are Incorporating it in our Departments
1:00PM - 2:00PM
Jeffrey Drebin, MD
Robert J. Motzer, MD
Andrew L Kung, MD, PhD
Next Generation of CAR-based Immunotherapies
2:00PM - 2:15PM
Michel Sadelain, MD, PhD, Director
Foundation for Accreditation of Cellular Therapy (FACT) Guidelines
2:15PM - 2:30PM
Helen Heslop, MD, DSc (Hon)
T-cell Collection, Production, and Delivery: Logistics & Regulation
2:30PM - 2:45PM
Sarah Nikiforow, MD
CIBMTR Guidelines for Cellular Therapies
2:45PM - 2:55PM
Miguel Perales, MD
Logistics of CAR T-cell Infusion
2:55PM - 3:05PM
Kevin J Curran, MD
Dual Antigen-targeted CARs
3:30PM - 3:45PM
Saar Gill, MD
HER2-specific CARs for Solid Tumors
3:45PM - 4:00PM
Stephen Gottschalk, MD
Heparanase-expressing CAR T cells for Solid Tumor Therapy
4:00PM - 4:15PM
Gianpietro  Dotti, MD
Mesothelin-targeted CARs
4:15PM - 4:30PM
Edmund Moon, MD
Combination Immunotherapeutic Approach for Solid Tumors
4:30PM - 4:45PM
Prasad S. Adusumilli, MD
Concluding Remarks
4:45PM - 5:00PM
Prasad S. Adusumilli, MD


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