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Journal-Based CME: Autoantibodies against type I IFNs in patients with critical influenza pneumonia


Journal-Based CME: Autoantibodies against type I IFNs in patients with critical influenza pneumonia Banner

  • Overview
  • Faculty
  • Course Content
Add to Calendar Journal-Based CME: Autoantibodies against type I IFNs in patients with critical influenza pneumonia 9/16/2022 10:00:00 AM 9/16/2025 10:00:00 AM America/New_York For More Details: https://mskcc.cloud-cme.com/course/courseoverview?P=0&EID=35584 Description: This Journal-Based CME activity consists of a full-text article that is free to read, a multiple-choice question test, and an evaluation/self-assessment. Learners are tested on their comprehension of the key concepts, with the objective of enriching their clinical practice and patient care through better understanding of scientific advances and new techniques in the fields covered by Journal of Exp... Online false MM/DD/YYYY


Date & Location
Friday, September 16, 2022, 10:00 AM - Tuesday, September 16, 2025, 10:00 AM

Specialties
Specialties - Allergy and Immunology, Bone Marrow Transplant, Epidemiology, General and Family Practice, Genetics, Hematology, Industry, Infectious Diseases, Integrative Medicine, Internal Medicine, Laboratory Medicine, Molecular Biology, Nurse Practitioner, Pediatrics, Pulmonology

Overview

This Journal-Based CME activity consists of a full-text article that is free to read, a multiple-choice question test, and an evaluation/self-assessment. Learners are tested on their comprehension of the key concepts, with the objective of enriching their clinical practice and patient care through better understanding of scientific advances and new techniques in the fields covered by Journal of Experimental Medicine (JEM). 

Questions for this complimentary, online-only activity have been designed by JEM editors in collaboration with the article authors. Each CME activity should take approximately 1 hour to complete.

The article selected for this activity is “Autoantibodies against type I IFNs in patients with critical influenza pneumonia,” by Qian Zhang and Jean-Laurent Casanova of the St. Giles Laboratory of Human Genetics of Infectious Diseases at The Rockefeller University, and colleagues.

Article Abstract

Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring autoantibodies neutralizing IFN-a2 alone (five patients) or with IFN-? (eight patients) from a cohort of 279 patients (4.7%) aged 6–73 yr with critical influenza pneumonia. Nine and four patients had antibodies neutralizing high and low concentrations, respectively, of IFN-a2, and six and two patients had antibodies neutralizing high and low concentrations, respectively, of IFN-?. The patients’ autoantibodies increased influenza A virus replication in both A549 cells and reconstituted human airway epithelia. The prevalence of these antibodies was significantly higher than that in the general population for patients <70 yr of age (5.7 vs. 1.1%, P = 2.2 × 10-5), but not >70 yr of age (3.1 vs. 4.4%, P = 0.68). The risk of critical influenza was highest in patients with antibodies neutralizing high concentrations of both IFN-a2 and IFN-? (OR = 11.7, P = 1.3 × 10-5), especially those <70 yr old (OR = 139.9, P = 3.1 × 10-10). We also identified 10 patients in additional influenza patient cohorts. Autoantibodies neutralizing type I IFNs account for ~5% of cases of life-threatening influenza pneumonia in patients <70 yr old.

 

Click the 'Course Content' tab at the top of this page to access the article and instructions on claiming CME credit

 

 About Journal of Experimental Medicine (JEM) and CME Activities

JEM publishes peer-reviewed papers within the field of medical biology, providing novel conceptual insights into immunology, cancer biology, neuroscience, inflammation, vascular biology, microbial pathogenesis, and stem cell biology. These studies range from original findings on all aspects of disease pathogenesis to novel therapeutic approaches. Articles designated for Journal-Based CME have been selected by JEM editors for their clinical relevance and ability to address practice-based gaps.



Objectives
  1. Comprehend key points in the research findings outlined in the activity.
  2. Differentiate between old and new concepts.
  3. Learners will have the information necessary to apply the relevant points to their clinical practice.

Accreditation

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Memorial Sloan Kettering Cancer Center, the Journal of Experimental Medicine (JEM) and Rockefeller University Press. Memorial Sloan Kettering Cancer Center is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

AMA Credit Designation Statement

Memorial Sloan Kettering Cancer Center designates this enduring material for a maximum of 1.00 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Recorded/Review Date: September 16, 2022; Original Release Date: September 16, 2022; Termination Date: September 16, 2025



Keywords: Complimentary CourseAMA PRA Category 1Journal-Based ActivityOn Demand Only



Faculty Member Information
Role in activity
Name of Ineligible Company(s) / Nature of Relationship(s)
Jean-Laurent Casanova, M.D., Ph.D.

Activity Director
Nothing to disclose
Carl F. Nathan, M.D.
Weill Cornell Medicine
Planner
Advisor-Pfizer, Inc.
Xin Sun, Ph.D.

Planner
Nothing to disclose
Rory Williams, BA
Rockefeller University Press
Planner
Nothing to disclose

Autoantibodies against type I IFNs in patients with critical influenza pneumonia

Qian Zhang, Andrés Pizzorno, Lisa Miorin, Paul Bastard, Adrian Gervais, Tom Le Voyer, Lucy Bizien, Jeremy Manry, Jérémie Rosain, Quentin philippot, Kelian Goavec, Blandine Padey, Anastasija Cupic, Emilie Laurent, Kahina Saker, Tamara Garcia-Salum, Marcela Ferres, Nicole Le Corre, Javier Sánchez Céspedes, María Balsera, Jordi Carratala, Pilar Retamar-Gentil, Gabriela Abelenda-Alonso, Adoración Valiente, Pierre Tiberghien, Marie Zins, Stéphanie Debette, Isabelle Meyts, Filomeen Haerynck, Riccardo Castagnoli, Luigi D Notarangelo, LUIS I GONZALEZ-GRANADO, Nerea Dominguez Pinilla, Evangelos Andreakos, Vasiliki Triantafyllia, Carlos Rodríguez-Gallego, Jordi Solé-Violán, José Juan Ruiz-Hernandez, Felipe Rodríguez de Castro, José Ferreres, Marisa Briones, Joost Wauters, Lore Vanderbeke, Simon Feys, Chen-Yen Kuo, Wei-Te Lei, Cheng-Lung Ku, Galit Tal, Amos Etzioni, Suhair Hanna, Thomas Fournet, jean-sebastien casalegno, Gregory Queromes, laurent argaud, Etienne Javouhey, Manuel Rosa-Calatrava, Elisa Cordero, Teresa Aydillo Gomez, Rafael A. Medina, Kai Kisand, Anne Puel, Emmanuelle Jouanguy, Laurent Abel, Aurelie Cobat, Sophie Trouillet-Assant, Adolfo Garcia-Sastre, Jean-Laurent Casanova

Activity Instructions

  • Click the blue 'Access Article' button below. The article will open in a new window.
  • When you have read the article in its entirety, return to this page and click the 'Post Test' button to take the test. You must be signed in to complete the test and claim CME credit. If this is your first time on the MSK CME site, please create an account. 

  • Select your answer to each of the three questions and click 'Check Answer', then click 'Next' in the upper right corner. After the last question of the test, click 'Show Results'. If you have passed, click 'CME Account' claim CME credit. 

  • On the window that opens, click 'Complete Evaluation' next to the activity name and attest to your participation.

  • A certificate will be generated and appear on the page in the same location. To navigate back to this page at any time, click 'MY CME' and 'Evaluations & Certificates'. 

Access Article Post-Test

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