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Journal-Based CME: The PML Hub: An Emerging Actor of Leukemia Therapies


Journal-Based CME: The PML Hub: An Emerging Actor of Leukemia Therapies Banner

  • Overview
  • Faculty
  • Course Content


Date & Location
Thursday, June 29, 2023, 10:00 AM - Monday, June 29, 2026, 8:00 PM

Specialties
Specialties - Bone Marrow Transplant, Breast Medical Oncology, Cellular Therapeutics, Gastrointestinal Oncology, General and Family Practice, Genitourinary Oncology, Gynecologic Oncology, Head and Neck Oncology, Hematology, Immunotherapy, Industry, Laboratory Medicine, Leukemia, Lymphoma, Medical Oncology, Molecular Biology, Neuro-Oncology, Nurse Practitioner, Oncology and Hematology, Pathology, Pediatrics, Pharmacology and Medication Management, Radiation Oncology, Solid Tumor Oncology, Surgical Oncology, Thoracic Medical Oncology

Overview

This Journal-Based CME activity consists of a full-text article that is free to read, a multiple-choice question test, and an evaluation/self-assessment. Learners are tested on their comprehension of the key concepts, with the objective of enriching their clinical practice and patient care through better understanding of scientific advances and new techniques in the fields covered by Journal of Experimental Medicine (JEM).

Questions for this complimentary, online-only activity have been designed by JEM editors in collaboration with the article authors. Each CME activity should take approximately 1 hour to complete.

The article selected for this activity is The PML hub: An emerging actor of leukemia therapies by Domitille Rérolle and Hugues de Thé of the Center for Interdisciplinary Research in Biology, Collège de France, Inserm, PSL Research University in Paris, France.

Article Abstract

Promyelocytic leukemia (PML) assembles into nuclear domains that have attracted considerable attention from cell and cancer biologists. Upon stress, PML nuclear bodies modulate sumoylation and other post-translational modifications, providing an integrated molecular framework for the multiple roles of PML in apoptosis, senescence, or metabolism. PML is both a sensor and an effector of oxidative stress. Emerging data has demonstrated its key role in promoting therapy response in several hematological malignancies. While these membrane-less nuclear hubs can enforce efficient cancer cell clearance, their downstream pathways deserve better characterization. PML nuclear bodies are druggable and their known modulators may have broader clinical utilities than initially thought.

About Journal of Experimental Medicine (JEM) and CME Activities

JEM publishes peer-reviewed papers within the field of medical biology, providing novel conceptual insights into immunology, cancer biology, neuroscience, inflammation, vascular biology, microbial pathogenesis, and stem cell biology. These studies range from original findings on all aspects of disease pathogenesis to novel therapeutic approaches. Articles designated for Journal-Based CME have been selected by JEM editors for their clinical relevance and ability to address practice-based gaps.

Select the 'Course Content' tab at the top of this page in order to access the full article and claim CME credit.


Accreditation

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Memorial Sloan Kettering Cancer Center, the Journal of Experimental Medicine (JEM) and Rockefeller University Press. Memorial Sloan Kettering Cancer Center is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

AMA Credit Designation Statement

Memorial Sloan Kettering Cancer Center designates this enduring material for a maximum of 1.00 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.



Recorded/Review Date: June 29, 2023 | Original Release Date: June 29, 2023 | Termination Date: June 29, 2026



Keywords: AMA PRA Category 1Journal-BasedComplimentary



Mitigation of Relevant Financial Relationships


Memorial Sloan Kettering Cancer Center adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CE activity, including faculty, planners, reviewers or others are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.

Member Information
Role in activity
Nature of Relationship(s) / Name of Ineligible Company(s)
Jean-Laurent Casanova, M.D., Ph.D.

Activity Director
Nothing to disclose
Sylvia Cuadrado, BA
Planner
Nothing to disclose
Xin Sun, Ph.D.
The Rockefeller University
Planner
Nothing to disclose
Rory Williams, BA
Rockefeller University Press
Planner
Nothing to disclose

The PML hub: An emerging actor of leukemia therapies
 
by Domitille Rérolle and Hugues de Thé of the Center for Interdisciplinary Research in Biology, Collège de France, Inserm, PSL Research University in Paris, France.

 

Activity Instructions

  • Click the blue 'Access Article' button below. The article will open in a new window.

 

  • When you have read the article in its entirety, return to this page and click the 'Post Test' button to take the test. You must be signed in to complete the test and claim CME credit. If this is your first time on the MSK CME site, please create an account. 

  • Select your answer to each of the three questions and click 'Check Answer', then click 'Next' in the upper right corner. After the last question of the test, click 'Show Results'. If you have passed, click 'CME Account' to claim CME credit. 

  • On the window that opens, click 'Complete Evaluation' next to the activity name and attest to your participation.

  • A certificate will be generated and appear on the page in the same location. To navigate back to this page at any time, click 'MY CME' and 'Evaluations & Certificates'. 
Access Article Post-Test


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