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2nd Annual Symposium on Advanced Therapeutics for Brain Metastasis: Moving the Needle and Controversies at the Cutting Edge


2nd Annual Symposium on Advanced Therapeutics for Brain Metastasis: Moving the Needle and Controversies at the Cutting Edge Banner

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Add to Calendar 2nd Annual Symposium on Advanced Therapeutics for Brain Metastasis: Moving the Needle and Controversies at the Cutting Edge 3/7/2024 8:00:00 AM 3/7/2024 5:00:00 PM America/New_York For More Details: https://mskcc.cloud-cme.com/course/courseoverview?EID=43108 Description: This didactic and case-based educational program will provide a comprehensive update on the latest advancements in the treatment and research of brain metastasis. Tailored for clinicians and translational scientists, this symposium will cover central nervous system (CNS)-specific outcomes from both molecular and traditional cancer histology viewpoints. Recent evidence for brain metastasis activity wil... Online false MM/DD/YYYY


Date & Location
Thursday, March 7, 2024, 8:00 AM - 5:00 PM, Online

Specialties
Specialties - Breast Medical Oncology, Genitourinary Oncology, Gynecologic Oncology, Medical Oncology, Neuro-Oncology, Neuroradiology, Neurosurgery, Oncology and Hematology, Radiation Oncology, Solid Tumor Oncology, Thoracic Medical Oncology

Overview

This didactic and case-based educational program will provide a comprehensive update on the latest advancements in the treatment and research of brain metastasis. Tailored for clinicians and translational scientists, this symposium will cover central nervous system (CNS)-specific outcomes from both molecular and traditional cancer histology viewpoints. 

Recent evidence for brain metastasis activity will be highlighted for key medical targets (e.g. Her2, EGFR, KRAS, CDK, BRAF, and ALK), and leading experts will review brain metastasis prognosis across the cancers commonly resulting in this (lung, breast, and melanoma).

A dedicated session on recent developments in local therapy will review the role of laser interstitial thermal therapy, brachytherapy, and external beam radiation techniques.

In recognition of the many complex treatment interactions imposed by multimodality treatment often necessary, a 'Key Controversies' session will speak to major areas of clinical difficulty, for example, how to distinguish on recurrent disease from radiation necrosis on imaging studies, when to change therapy with CNS-only progressive disease, which leptomeningeal metastasis interventions are currently worthwhile, and special considerations regarding steroid use and radiation therapy for patients requiring immunotherapy.

Key scientists will discuss promising translational and clinical trial approaches including targeting metastasis-initiating cells and window-of-opportunity studies.

Given the special challenge of early detection, a dedicated session will cover state-of-the art molecular imaging techniques, the evidence for/against imaging surveillance in standard-risk cancers, and the current state of liquid biopsy.

A roundtable discussion with participants from several centers will share their experiences and best practices with multidisciplinary team care and discuss areas for improvement. Finally, a multidisciplinary tumor board will review multifaceted cases, highlighting the interplay of various treatment options.

This symposium is set to be an exclusively live virtual experience with ample opportunity to network and engage with speakers and other participants.

Target Audience

This symposium is intended for neurosurgeons, radiation oncologists, neurologists and neuro-oncologists, physicians in training, and other allied health professionals who treat and manage patients with metastatic disease.

Online Syllabus

Attendees will receive access to an online syllabus after the symposium, which includes select PDFs of presentations (slides) and video recordings of the lectures.

Objectives
At the conclusion of this symposium, learners will be able to:

  1. Describe the current multimodal landscape of brain metastasis treatment
  2. Identify key clinical controversies in brain metastasis management
  3. Discuss barriers to improved treatments and potential research strategies (e.g. limited CNS activity of systemic anti-cancer treatments, side effects of local treatments, limited survival, and unclear endpoints)

Registration

This symposium is complimentary for all to attend. Please complete registration through the 'Register' tab above. Detailed Zoom access and participation instructions will be provided to registrants prior to the start of the program. We kindly request that those who register also plan to attend. If you are registered for this symposium and are unable to attend, please notify us by emailing [email protected].

Industry professionals may attend MSK CME activities for their own education. Marketing, sales, and promotion of products and services is strictly prohibited at MSK CME activities. For more information, please visit our Help 


Accreditation

Memorial Sloan Kettering Cancer Center is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

AMA Credit Designation Statement

Memorial Sloan Kettering Cancer Center designates this live activity for a maximum of 7.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

MOC/CC Recognition Statements

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

  • 7.75 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program; and
  • 7.75 Lifelong Learning (CME) credits in the American Board of Pathology’s (ABPath) Continuing Certification program. 

It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM or ABPath MOC/CC credit.



Keywords: ABIM MOCAMA PRA Category 1 ABPath CC



MSK Symposium Director

Nelson Moss, MD
Co-Director, Multidisciplinary Brain Metastasis Program
Associate Attending
Department of Neurosurgery

 

MSK Symposium Co-Director 

Adrienne A. Boire, MD, PhD
Geoffrey Beene Junior Faculty Chair
Associate Attending
Department of Neurology 

 

Invited Symposium Faculty

Allison Betof Warner, MD, PhD
Assistant Professor of Medicine (Oncology)
Mark and Mary Stevens Endowed Scholar in Melanoma
Director, Melanoma Program
Director, Solid Tumor Cellular Therapy 
Stanford University School of Medicine
Stanford, CA

Qing Chen, MD, PhD
Assistant Professor
Immunology Microenvironment & Metastasis
The Wistar Institute
Philadelphia, PA

Professor Rebecca Dent, MD FRCP (Canada)
Deputy Chief Executive Officer (Clinical)
Senior Consultant, Dept of Breast & Gynaecology
Division of Medical Oncology, National Cancer Centre Singapore
Duke-NUS Medical School
Singapore


Benjamin Ellingson, PhD
Professor and Director of MRI Research
Director, UCLA Brain Tumor Imaging Laboratory
Departments of Radiology, Psychiatry, and Neurosurgery
David Geffen School of Medicine
University of California Los Angeles
Los Angeles, CA

Melanie Hayden Gephart, MD, MAS
Professor of Neurosurgery
Director, Stanford Brain Tumor Center
Stanford, CA

Sarah Goldberg, MD, MPH
Associate Professor of Medicine, Medical Oncology
Division Chief of Thoracic Oncology
Research Director, Center for Thoracic Cancers
Associate Program Director, Medical Oncology-Hematology Fellowship Program
Yale School of Medicine
New Haven, CT


Priya Kumthekar, MD
Associate Professor of Neurology (Neuro-oncology) and Medicine (Hematology and Oncology)
Director of the Brain Metastases Program 
Northwestern University
Feinberg School of Medicine
Chicago, IL


Emilie Le Rhun, MD, PhD
Attending Physician
University of Zurich
Zurich, Switzerland

Julia Maues
Co-founder 
GRASP – Guiding Researchers and Advocates to Scientific Partnerships
Baltimore, MD

Minesh P. Mehta, MD
Deputy Director and Chief of Radiation Oncology 
Miami Cancer Institute
Member, Memorial Sloan Kettering Cancer Alliance
Miami, FL

Peter Siegel, PhD
Professor, Department of Medicine
Full Member, Rosalind and Morris Goodman Cancer Institute
Associate Member, Departments of Biochemistry, Anat. & Cell Biology and Oncology
McGill University 
Montreal, Canada

Paul W. Sperduto, MD, MPP, FASTRO
Adjunct Professor
Department of Radiation Oncology
Duke School of Medicine
Durham, North Carolina

Hussein Tawbi, MD, PhD
Deputy Chair, Department of Melanoma Medical Oncology
Co-Director, Andrew M. McDougall Brain Metastasis Clinic & Program
The University of Texas MD Anderson Cancer Center
Houston, TX


Nicole Willmarth, PhD
Chief Mission Officer
American Brain Tumor Association 
Chicago, IL

Alexandra Zimmer, MD, MSc
Associate Professor, Hematology & Medical Oncology Division
Breast Cancer Program Director
OHSU, Knight Cancer Institute
Portland, OR



MSK Symposium Faculty 

Joshua Budhu, MD, MS, MPH
Assistant Attending
Nicholls-Biondi Diversity Clinical Scientist Faculty Scholar
Department of Neurology

Robert Daly, MD, MBA
Assistant Attending
Department of Medicine 

Alexander Drilon, MD
Chief, Early Drug Development Service
Department of Medicine 

Siting Gan, PhD
Postdoctoral Researcher
Department of Cancer Biology and Genetics

Brandon Imber, MD, MA
Assistant Attending
Department of Radiation Oncology

Mark G. Kris, MD
William and Joy Ruane Chair in Thoracic Oncology 
Attending
Department of Medicine


Bob T. Li, MD, PhD, MPH
Physician Ambassador to China and Asia-Pacific, Bobst International Center
Co-Director, Thoracic Liquid Biopsy Program
Chief Scientific Officer, MSK Direct
Associate Attending
Department of Medicine  

Shanu Modi, MD
Attending Physician
Department of Medicine

Michael A. Postow, MD
Chief, Melanoma Service
Co-Director, Melanoma Disease Management Team
Department of Medicine 

Gregory Riely, MD, PhD
Attending Physician
Vice Chair of Clinical Research
Department of Medicine

Andrew D. Seidman, MD
Attending Physician
Breast Medicine Service
Department of Medicine

Robert J. Young, MD
Director, 3T Neuroradiology Imaging
Attending Radiologist 
Neuroradiology Service
Department of Radiology 



Mitigation of Relevant Financial Relationships


Memorial Sloan Kettering Cancer Center adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CE activity, including faculty, planners, reviewers, or others are required to disclose all financial relationships with ineligible companies (commercial interests). All relevant financial relationships have been mitigated prior to the commencement of the activity.



Member Information
Role in activity
Nature of Relationship(s) / Name of Ineligible Company(s)
Adrienne Boire, MD, PhD
MSK
Activity Co-Director, Conflict of Interest Peer Reviewer, Faculty
Nothing to disclose
Nelson Moss, MD
MSK
Activity Director, Faculty
Consulting Fee-AstraZeneca (Relationship has ended)|Grant or research support-GT Medical Technologies|Grant or research support-AstraZeneca
Joshua A Budhu, MD, MPH
MSK
Usa
Conflict of Interest Peer Reviewer, Faculty
Nothing to disclose
Allison Betof Warner, MD, PhD
Stanford University School of Medicine
Faculty
Consulting Fee-Bristol-Myers Squibb|Consulting Fee-BluePath Solutions (Relationship has ended)|Consulting Fee-Immatics (Relationship has ended)|Consulting Fee-Iovance Biotherapeutics|Grant or research support-Iovance Biotherapeutics|Consulting Fee-Lyell Immunopharma (Relationship has ended)|Consulting Fee-Novartis AG (Relationship has ended)|Consulting Fee-Merck and Company, Inc. (Relationship has ended)|Consulting Fee-Pfizer, Inc.
Qing Chen, MD, PhD
The Wistar Institute
Faculty
Nothing to disclose
Robert Daly , MD
MSK
Faculty
Nothing to disclose
Rebecca Dent, MD, MSc, FRCP
National University of Singapore
Singapore
Faculty
Advisor-AstraZeneca|Advisor-Roche|Advisor-Merck and Company, Inc.|Advisor-Pfizer, Inc.|Advisor-Novartis AG|Honoraria-AstraZeneca|Honoraria-Pfizer, Inc.|Honoraria-Roche|Honoraria-Merck and Company, Inc.|Grant or research support-AstraZeneca
Faculty Photos
Alexander Drilon, MD
MSK
Faculty
Stocks or stock options, excluding diversified mutual funds-Equity: mBrace, Treeline|Royalties or Patent Beneficiary-Selpercatinib-Osimertinib (filed/pending): patent number initially WO2022046867, now US 18/041,617|Advisor-AnHeart Therapeutics
Benjamin Ellingson, PhD
UCLA
Faculty
Advisor-Alpheus Medical|Advisor-Chimerix|Advisor-Erasca |Advisor-Global Coalition for Adaptive Research |Advisor-Imaging Endpoints |Advisor-Medicenna|Advisor-Voiant |Advisor-Monteris |Advisor-Neosoma |Advisor-Orbus Therapeutics |Advisor-Sagimet Biosciences|Advisor-Sapience Therapeutics |Advisor-Servier|Advisor-Siemens AG|Advisor-SonALAsense|Advisor-Sumitomo Dainippon Pharma Oncology
Siting Gan, PhD
MSK
Faculty
Nothing to disclose
Sarah Goldberg, MD, MPH
Yale School of Medicine
Faculty
Grant or research support-AstraZeneca|Grant or research support-Mirati|Grant or research support-Boehringer Ingelheim Vetmedica GmbH|Advisor-AstraZeneca|Advisor-Daiichi Sankyo|Advisor-Johnson and Johnson|Advisor-Summit Therapeutics|Advisor-Merck and Company, Inc.|Advisor-Regeneron
Melanie Hayden Gephart, MD, MAS
Stanford
Faculty
Grant or research support-Quadriga Bioscience|Stocks or stock options, excluding diversified mutual funds-Smart Lens|Consulting Fee-Robeaute |Consulting Fee-Midatech/Biodexa Pharmaceutical (Relationship has ended)|Stocks or stock options, excluding diversified mutual funds-SensoBrain |Consulting Fee-Telix
Brandon Imber, MD
MSK
Faculty
Honoraria-GT Medical Technologies|Grant or research support-Novartis AG|Grant or research support-Bayer Corporation|Grant or research support-AstraZeneca|Grant or research support-Kazia|Honoraria-Telix (Relationship has ended)
Mark G Kris, MD
MSKCC, New York
Faculty
Honoraria-AstraZeneca (Relationship has ended)|Consulting Fee-Pfizer, Inc.|Consulting Fee-Merus (Relationship has ended)|Consulting Fee-BirGenBio (Relationship has ended)|Advisor-Mirati|Consulting Fee-Sanofi (Relationship has ended)
Priya Kumthekar, MD
Northwestern
Faculty
Advisor-Enclear|Consulting Fee-Biocept (Relationship has ended)|Consulting Fee-Belay Diagnostics |Advisor-Servier|Advisor-Novocure|Consulting Fee-Plus Therapeutics |Advisor-Affinia Therapeutics (Relationship has ended)|Consulting Fee-Bioclinical/Clario (Relationship has ended)|Advisor-Telix Pharmaceuticals|Advisor-Biodexa (Relationship has ended)|Speakers Bureau-Seagen|Consulting Fee-BPGbio|Consulting Fee-In8bio
Emilie Le Rhun, MD, PhD
University Hospital Zurich
Switzerland
Faculty
Advisor-Servier (Relationship has ended)|Advisor-Leo Pharma (Relationship has ended)|Consulting Fee-Roche|Honoraria-AstraZeneca (Relationship has ended)|Consulting Fee-Pfizer, Inc. (Relationship has ended)|Advisor-Bayer Corporation (Relationship has ended)|Honoraria-Pierre Fabre (Relationship has ended)|Honoraria-Seagen (Relationship has ended)
Bob T. Li, MD
MSK
Faculty
Grant or research support-Amgen|Grant or research support-AstraZeneca|Grant or research support-Daiichi Sankyo|Grant or research support-Eli Lilly and Company|Grant or research support-Hengrui USA (Relationship has ended)|Grant or research support-Bolt Biotherapeutics|Grant or research support-Genentech, Inc.
Julia Maues, MA
GRASP
Faculty
Nothing to disclose
Minesh Mehta, MD
Miami Cancer Institute
Faculty
Nothing to disclose
Shanu Modi, MD
MSK
Faculty
Grant or research support-Genentech, Inc.|Honoraria-AstraZeneca|Grant or research support-Daiichi Sankyo|Grant or research support-AstraZeneca|Consulting Fee-Genentech, Inc.|Consulting Fee-AstraZeneca|Consulting Fee-Daiichi Sankyo|Advisor-macrogenics|Grant or research support-seattle genetics|Honoraria-Daiichi Sankyo|Honoraria-seattle genetics|Consulting Fee-GlaxoSmithKline (Relationship has ended)|Consulting Fee-Novartis AG (Relationship has ended)
Michael Postow, MD
MSK
Faculty
Consulting Fee-Merck and Company, Inc.|Grant or research support-Bristol-Myers Squibb|Grant or research support-Merck and Company, Inc.|Consulting Fee-Chugai|Consulting Fee-Bristol-Myers Squibb|Consulting Fee-Eisai, Inc.|Consulting Fee-Pfizer, Inc.
Gregory Riely, MD
MSK
Faculty
Grant or research support-Mirati|Grant or research support-Takeda Pharmaceuticals, Inc.|Grant or research support-Eli Lilly and Company|Grant or research support-Roche|Grant or research support-Pfizer, Inc.|Grant or research support-Merck and Company, Inc.|Grant or research support-Novartis AG
Andrew D Seidman, MD
MSK
Faculty
Consulting Fee-Genentech, Inc.|Honoraria-Genentech, Inc.|Consulting Fee-Gilead|Honoraria-Gilead|Consulting Fee-Eli Lilly and Company|Honoraria-Eli Lilly and Company|Consulting Fee-Novartis AG|Honoraria-Novartis AG|Consulting Fee-Pfizer, Inc. (Relationship has ended)|Honoraria-Pfizer, Inc. (Relationship has ended)|Advisor-Osmol Therapeutics|Advisor-Samus (Relationship has ended)|Consulting Fee-BeyondSpring (Relationship has ended)|Consulting Fee-Athenex (Relationship has ended)|Honoraria-AstraZeneca|Honoraria-Immunomedics (Relationship has ended)|Consulting Fee-Daiichi Sankyo (Relationship has ended)|Honoraria-Stemline Therapeutics
Peter M. Siegel, PhD
McGill University
Canada
Faculty
Nothing to disclose
Paul W Sperduto, MD, MD, MPP, FASTRO
Duke
Faculty
Independent Contractor (included contracted research)-Varian (Relationship has ended)
Viviane Tabar, MD
MSK
Faculty
Advisor-BlueRock Therapeutics
Hussein Tawbi, MD, PhD
The University of Texas MD Anderson Cancer Center
Faculty
Advisor-Bristol-Myers Squibb|Grant or research support-Bristol-Myers Squibb|Advisor-Merck and Company, Inc.|Grant or research support-Merck and Company, Inc.|Advisor-Genentech, Inc. (Relationship has ended)|Grant or research support-Genentech, Inc.|Consulting Fee-Eisai, Inc.|Consulting Fee-Novartis AG (Relationship has ended)|Grant or research support-Novartis AG|Consulting Fee-Pfizer, Inc.|Grant or research support-GlaxoSmithKline|Consulting Fee- Karyopharm, Iovance, Medicenna, and Jazz Pharmaceuticals
Nicole Willmarth, PhD
American Brain Tumor Association
Faculty
Nothing to disclose
Robert Young, MD
MSK
Faculty
Consulting Fee-Olea Medical|Consulting Fee-Turing|Independent Contractor (included contracted research)-RadMD|Consulting Fee-NordicNeuroLab|Independent Contractor (included contracted research)-ICON plc
Alexandra Zimmer, MD, MSc
OHSU
Faculty
Advisor-Pfizer, Inc. (Relationship has ended)

Thursday, March 7, 2024

Relevant Financial Relationships
8:00AM - 8:05AM

View faculty disclosures here
Challenges and Successes of Early Drug Development for Brain Metastasis
8:05AM - 8:30AM
Alexander Drilon, MD
The Role of Patient Involvement in Advancing Brain Metastasis Care
8:30AM - 8:35AM
Julia Maues, MA
Multi-Stakeholder Collaborations to Advance Brain Metastasis Research
8:35AM - 8:40AM
Nicole Willmarth, PhD
Keynote Address Panel Discussion
8:40AM - 8:45AM
Nelson Moss, MD (Moderator)
Melanoma Brain Metastases: Successes, Failures, and Future Opportunities
8:45AM - 9:00AM
Michael Postow, MD
Lung Cancer Brain Metastases
9:00AM - 9:15AM
Sarah Goldberg, MD, MPH
The Evolution of Brain Metastases in Breast Cancer
9:15AM - 9:30AM
Rebecca Dent, MD, MSc, FRCP
CNS Outcomes with Modern Radiation Approaches
9:30AM - 9:45AM
Minesh Mehta, MD
The Changing Prognoses of Brain Metastatic Diseases Panel Discussion
9:45AM - 9:55AM
Adrienne Boire, MD, PhD (Moderator)
Clinical Trials Landscape for Leptomeningeal Metastasis
10:05AM - 10:15AM
Priya Kumthekar, MD
Novel Immunotherapy Strategies for Melanoma Brain Metastasis
10:15AM - 10:30AM
Allison Betof Warner, MD, PhD
Window of Opportunity Neurosurgical Trials
10:30AM - 10:45AM
Nelson Moss, MD
Frontiers in Breast Cancer Brain Metastasis: Antibody-drug Conjugate Effectiveness in the CNS
10:45AM - 11:00AM
Shanu Modi, MD
Clinical Trials Panel Discussion
11:00AM - 11:10AM
Priya Kumthekar, MD (Moderator)
Treatment Sequencing in Melanoma Brain Metastasis: When Can Local Therapy be Foregone?
11:10AM - 11:25AM
Hussein Tawbi, MD, PhD
CNS Surveillance for Asymptomatic Cancer Patients
11:25AM - 11:40AM
Emilie Le Rhun, MD, PhD

No video will be posted for this presentation.
Changing Systemic Therapy Post Oligoprogression in the CNS
11:40AM - 11:55AM
Gregory Riely, MD
Controversies Panel Discussion
11:55AM - 12:00PM
Nelson Moss, MD (Moderator)
State-of-the-Art Imaging for Brain Metastasis
1:00PM - 1:15PM
Benjamin Ellingson, PhD
CSF Liquid Biopsy for Brain Metastasis
1:15PM - 1:30PM
Melanie Hayden Gephart, MD, MAS
Chemoprevention of Brain Metastasis
1:30PM - 1:45PM
Alexandra Zimmer, MD, MSc
Prevention Panel Disccussion
1:45PM - 1:50PM
Nelson Moss, MD (Moderator)
Collecting and Integrating Multimodal Data
1:50PM - 2:05PM
Paul W Sperduto, MD, MD, MPP, FASTRO
Innovations in Local Care Delivery for Patients with Advanced Cancer and Neurologic Impairment
2:05PM - 2:20PM
Robert Daly , MD
Accelerating Cancer Cures Through International Clinical Trials R&D
2:20PM - 2:35PM
Bob T. Li, MD
Advancing Equitable Care for Patients with Brain Metastasis
2:35PM - 2:50PM
Joshua A Budhu, MD, MPH
Expanding Reach: From Patient Level to Population Level Panel Discussion
2:50PM - 2:55PM
Bob T. Li, MD (Moderator)
Characterizing the Immune Microenvironments of Brain Metastases
3:00PM - 3:15PM
Peter M. Siegel, PhD
Distinct Tumor Architectures and Microenvironments for Brain Metastasis Initiation
3:15PM - 3:30PM
Siting Gan, PhD
Type I IFN Response in Brain Metastasis
3:30PM - 3:45PM
Qing Chen, MD, PhD
Microenvironmental Signals Metabolically Reprogram Leptomeningeal Cancer Cells
3:45PM - 4:00PM
Adrienne Boire, MD, PhD
Basic and Translational Science Panel Discussion
4:00PM - 4:05PM
Adrienne Boire, MD, PhD (Moderator)
Multidisciplinary Tumor Board
4:15PM - 4:55PM
Adrienne Boire, MD, PhD (Moderator)
Joshua A Budhu, MD, MPH
Brandon Imber, MD
Nelson Moss, MD
Andrew D Seidman, MD
Robert Young, MD
Mark G Kris, MD

Memorial Sloan Kettering gratefully acknowledges the following organizations for providing educational grants for this live activity:

GT Medical Technologies, Inc.
Varian a Siemens Healthineers Company


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